Chemistry
The composition and transformation of matter.
32 courses from MIT OpenCourseWare.
5.05 · Graduate · Spring 2005
This course covers the principles of main group (s and p block) element chemistry with an emphasis on synthesis, structure, bonding, and reaction mechanisms.
5.07SC · Undergraduate · Fall 2013
<p>This course examines the chemical and physical properties of the cell and its building blocks, with special emphasis on the structures of proteins and principles of catalysis, as well as the chemistry of organic / inorganic cofactors required for chemical transformations within the cell. Topics encompass the basic principles of metabolism and regulation in pathways, including glycolysis, gluconeogenesis, fatty acid synthesis / degradation, pentose phosphate pathway, Krebs cycle and oxidative…
5.12 · Undergraduate · Spring 2003
5.12 is an introduction to organic chemistry, focusing primarily on the basic principles to understand the structure and reactivity of organic molecules. Emphasis is on substitution and elimination reactions and chemistry of the carbonyl group. The course also provides an introduction to the chemistry of aromatic compounds.
5.12 · Undergraduate · Spring 2005
This subject deals primarily with the basic principles to understand the structure and reactivity of organic molecules. Emphasis is on substitution and elimination reactions and chemistry of the carbonyl group. The course also provides an introduction to the chemistry of aromatic compounds.
5.13 · Undergraduate · Fall 2003
This intermediate organic chemistry course focuses on the methods used to identify the structure of organic molecules, advanced principles of organic stereochemistry, organic reaction mechanisms, and methods used for the synthesis of organic compounds. Additional special topics include illustrating the role of organic chemistry in biology, medicine, and industry.
5.13 · Undergraduate · Fall 2006
This intermediate organic chemistry course focuses on the methods used to identify the structure of organic molecules, advanced principles of organic stereochemistry, organic reaction mechanisms, and methods used for the synthesis of organic compounds. Additional special topics include illustrating the role of organic chemistry in biology, medicine, and industry.
5.35 · Undergraduate · Fall 2012
<p>This course is the first part of a modular sequence of increasingly sophisticated (and challenging) laboratory courses required of all Chemistry majors: 5.35 Introduction to Experimental Chemistry, 5.36 Biochemistry and Organic Laboratory, 5.37 Organic and Inorganic Laboratory, and 5.38 Physical Chemistry Laboratory. This course provides students with a survey of spectroscopy, and introduces synthesis of coordination compounds and kinetics.</p> <p>This class is part of the new…
5.36 · Undergraduate · Spring 2009
<p>The course, which spans two thirds of a semester, provides students with a research-inspired laboratory experience that introduces standard biochemical techniques in the context of investigating a current and exciting research topic, acquired resistance to the cancer drug Gleevec. Techniques include protein expression, purification, and gel analysis, PCR, site-directed mutagenesis, kinase activity assays, and protein structure viewing.</p> <p>This class is part of the new laboratory curricul…
5.37 · Undergraduate · Spring 2009
<p>This course, which spans a third of a semester, provides students with experience using techniques employed in synthetic organic chemistry. It also introduces them to the exciting research area of catalytic chiral catalysis.</p> <p>This class is part of the new laboratory curriculum in the MIT Department of Chemistry. Undergraduate Research-Inspired Experimental Chemistry Alternatives (URIECA) introduces students to cutting edge research topics in a modular format.</p>
5.43 · Undergraduate · Spring 2007
This course deals with the application of structure and theory to the study of organic reaction mechanisms: Stereochemical features including conformation and stereoelectronic effects; reaction dynamics, isotope effects and molecular orbital theory applied to pericyclic and photochemical reactions; and special reactive intermediates including carbenes, carbanions, and free radicals.
5.60 · Undergraduate · Spring 2008
<p>This subject deals primarily with equilibrium properties of macroscopic systems, basic thermodynamics, chemical equilibrium of reactions in gas and solution phase, and rates of chemical reactions.</p> Acknowledgements <p>The material for 5.60 has evolved over a period of many years, and therefore several faculty members have contributed to the development of the course contents. The following are known to have assisted in preparing the lecture notes available on OpenCourseWare: Emeritus Prof…
5.61 · Undergraduate · Fall 2007
<p>This course presents an introduction to quantum mechanics. It begins with an examination of the historical development of quantum theory, properties of particles and waves, wave mechanics and applications to simple systems — the particle in a box, the harmonic oscillator, the rigid rotor and the hydrogen atom. The lectures continue with a discussion of atomic structure and the Periodic Table. The final lectures cover applications to chemical bonding including valence bond and molecular orbit…
5.61 · Undergraduate · Fall 2017
This course is an introduction to quantum mechanics for <em>use</em> by chemists. Topics include particles and waves, wave mechanics, semi-classical quantum mechanics, matrix mechanics, perturbation theory, molecular orbital theory, molecular structure, molecular spectroscopy, and photochemistry. Emphasis is on creating and building confidence in the use of intuitive pictures.
5.62 · Undergraduate · Spring 2008
<p>This course covers elementary statistical mechanics, transport properties, kinetic theory, solid state, reaction rate theory, and chemical reaction dynamics.</p> Acknowledgements <p>The staff for this course would like to acknowledge that these course materials include contributions from past instructors, textbooks, and other members of the MIT Chemistry Department affiliated with course #5.62. Since the following works have evolved over a period of many years, no single source can be attrib…
5.067 · Graduate · Fall 2009
This course in crystal structure refinement examines the practical aspects of crystal structure determination from data collection strategies to data reduction and basic and advanced refinement problems of organic and inorganic molecules.
5.069 · Graduate · Spring 2010
This course covers the following topics: X-ray diffraction: symmetry, space groups, geometry of diffraction, structure factors, phase problem, direct methods, Patterson methods, electron density maps, structure refinement, how to grow good crystals, powder methods, limits of X-ray diffraction methods, and structure data bases.
5.72 · Graduate · Spring 2012
This course discusses the principles and methods of non-equilibrium statistical mechanics. Basic topics covered are stochastic processes, regression and response theory, molecular hydrodynamics, and complex liquids. Selected applications, including fluctuation theorems, condensed phase reaction rate theory, electron transfer dynamics, enzymatic networks, photon counting statistics, single molecule kinetics, reaction-controlled diffusion, may also be discussed.
5.73 · Graduate · Fall 2005
5.73 covers fundamental concepts of quantum mechanics: wave properties, uncertainty principles, Schrödinger equation, and operator and matrix methods. Basic applications of the following are discussed: one-dimensional potentials (harmonic oscillator), three-dimensional centrosymmetric potentials (hydrogen atom), and angular momentum and spin. The course also examines approximation methods: variational principle and perturbation theory.
5.73 · Graduate · Fall 2018
This course presents the fundamental concepts of quantum mechanics: wave properties, uncertainty principles, the Schrödinger equation, and operator and matrix methods. Key topics include commutation rule definitions of scalar, vector, and spherical tensor operators; the Wigner-Eckart theorem; and 3j (Clebsch-Gordan) coefficients. In addition, we deal with many-body systems, exemplified by many-electron atoms (“electronic structure”), anharmonically coupled harmonic oscillators (“intramolecular …
5.74 · Graduate · Spring 2009
This course covers topics in time-dependent quantum mechanics, spectroscopy, and relaxation, with an emphasis on descriptions applicable to condensed phase problems and a statistical description of ensembles.
5.74 · Graduate · Spring 2004
This course covers time-dependent quantum mechanics and spectroscopy. Topics include perturbation theory, two-level systems, light-matter interactions, relaxation in quantum systems, correlation functions and linear response theory, and nonlinear spectroscopy.
5.80 · Graduate · Fall 2008
The goal of this course is to illustrate the spectroscopy of small molecules in the gas phase: quantum mechanical effective Hamiltonian models for rotational, vibrational, and electronic structure; transition selection rules and relative intensities; diagnostic patterns and experimental methods for the assignment of non-textbook spectra; breakdown of the Born-Oppenheimer approximation (spectroscopic perturbations); the stationary phase approximation; nondegenerate and quasidegenerate perturbati…
5.111 · Undergraduate · Fall 2008
<p>This course provides an introduction to the chemistry of biological, inorganic, and organic molecules. The emphasis is on basic principles of atomic and molecular electronic structure, thermodynamics, acid-base and redox equilibria, chemical kinetics, and catalysis.</p> <p>In an effort to illuminate connections between chemistry and biology, a list of the biology-, medicine-, and MIT research-related examples used in 5.111 is provided in Biology-Related Examples.</p> Acknowled…
5.111SC · Undergraduate · Fall 2014
<p>This course provides an introduction to the chemistry of biological, inorganic, and organic molecules. The emphasis is on basic principles of atomic and molecular electronic structure, thermodynamics, acid-base and redox equilibria, chemical kinetics, and catalysis. One year of high school chemistry is the expected background for this freshman-level course.</p> <p>The aims include developing a unified and intuitive view of how electronic structure controls the three-dimensional shape of mole…
5.112 · Undergraduate · Fall 2005
5.112 is an introductory chemistry course for students with an unusually strong background in chemistry. Knowledge of calculus equivalent to MIT course 18.01 is recommended. Emphasis is on basic principles of atomic and molecular electronic structure, thermodynamics, acid-base and redox equilibria, chemical kinetics, and catalysis. The course also covers applications of basic principles to problems in metal coordination chemistry, organic chemistry, and biological chemistry.
5.301 · Undergraduate · January IAP 2012
<p>This course is an intensive introduction to the techniques of experimental chemistry and gives first year students an opportunity to learn and master the basic chemistry lab techniques for carrying out experiments. Students who successfully complete the course and obtain a “Competent Chemist” (CC) or “Expert Experimentalist” (EE) rating are likely to secure opportunities for research work in a chemistry lab at MIT.</p> Acknowledgements <p>The laboratory manual and materials for this course w…
5.310 · Undergraduate · Fall 2019
<p>This course introduces experimental chemistry for students who are not majoring in chemistry. The course covers principles and applications of chemical laboratory techniques, including preparation and analysis of chemical materials, measurement of pH, gas and liquid chromatography, visible-ultraviolet spectrophotometry, infrared spectroscopy, nuclear magnetic resonance, mass spectrometry, polarimetry, X-ray diffraction, kinetics, data analysis, and organic synthesis.</p> Acknowledgements <p>…
5.512 · Graduate · Spring 2005
This course focuses on general methods and strategies for the synthesis of complex organic molecules. Emphasis is on strategies for stereoselective synthesis, including stereocontrolled synthesis of complex acyclic compounds.
ES.287 · Undergraduate · Spring 2009
This seminar is designed to be an experimental and hands-on approach to applied chemistry (as seen in cooking). Cooking may be the oldest and most widespread application of chemistry and recipes may be the oldest practical result of chemical research. We shall do some cooking experiments to illustrate some chemical principles, including extraction, denaturation, and phase changes.
RES.5-0001 · Undergraduate · Spring 2007
<p>The “Digital Lab Techniques Manual” is a series of videos designed to help you prepare for your chemistry laboratory class. Each video provides a detailed demonstration of a common laboratory technique, as well as helpful tips and information. These videos are meant to supplement, and not replace, your lab manual and assigned reading. In fact, you will most benefit from watching the videos if you have already read the appropriate background information. To be a great experimentalist, you mus…
RES.HS-002 · High School
<p><em>Chemistry Behind the Magic</em> features videos of exciting live chemistry demonstrations. The videos are enhanced by explanations of the science behind the demonstration, in a fun and easy-to-understand format.</p> <p>This set of videos showcases exciting live chemistry demonstrations held at MIT. Through the magic of chemistry, Dr. John Dolhun and Dr. Bassam Shakhashiri create things that steam, fizzle, and glow. Each video also provides a deeper look into the chemistry that makes it a…
RES.HS-003 · High School
<p>Each year, groups of MIT freshmen are introduced to MIT’s laboratory environment through a four-week intensive January course called <em>5.301 Chemistry Lab Techniques</em>. The stakes are high—students who pass the class are guaranteed a job in an MIT research lab. </p> <p>OpenCourseWare documented the experience of 14 students who took this course in January 2012. Follow their journey over 11 episodes and watch as they struggled with, but ultimately mastered, the techniques needed to …