Introduction to Computational Molecular Biology

This course introduces the basic computational methods used to understand the cell on a molecular level. It covers subjects such as the sequence alignment algorithms: dynamic programming, hashing, suffix trees, and Gibbs sampling. Furthermore, it focuses on computational approaches to: genetic and physical mapping; genome sequencing, assembly, and annotation; RNA expression and secondary structure; protein structure and folding; and molecular interactions and dynamics.

The syllabus, on MIT OpenCourseWare

The full course — syllabus, assigned readings, problem sets, exams, and lecture notes — lives on OCW. These open the real thing: